Not at all. Although cards are stored on the Ethereum network, players only interact on the network when they want to trade cards with other players. All other events in the game run using industry standard technologies like Unity, allowing gameplay to be indistinguishable from other games that don’t employ distributed ledgers.
That said, we’re obsessed with the Ethereum network’s ability to store digital assets as well as host its own currency (Ether or ETH). It’s one of the main reasons we started Gods Unchained to begin with. This opens gaming up to so many possibilities that can bring the medium forward in leaps and bounds, and we’re already looking at ways to make that accessible to mainstream audiences who aren’t familiar with the network through the creation of Immutable X.